In ~ 85% of cases, FH is caused by heterozygous pathogenic variants in the low-density lipoprotein receptor gene, LDLR (OMIM #143890); less often, by heterozygous variants in the apolipoprotein B-100 gene, APOB (OMIM #144010) or in the proprotein convertase subtilisin/kexin type 9 gene, PCSK9 (OMIM #603776) [Youngblom et al. 1993]. This evidence concerns the gene PCSK9 and familial hyperaldosteronism.