Since ANKRD11 interacts with several key proteins of chromatin remodeling complexes, such as histone deacetylases and acetyltransferases, nuclear co-receptors, etc. and regulates global gene expression [29], it is unsurprising that mouse ANKRD11 regulates development and/or functioning of multiple tissues [29–31], and KBG syndrome patients report systemic phenotypes affecting multiple organs. The gene discussed is ANKRD11; the disease is KBG syndrome.