Given the high expression levels of ACE2 in the glandular cells of the intestine and the presence of viral nucleocapsid proteins in gastrointestinal epithelial cells and glandular enterocytes57,58, we aimed to understand whether SARS-CoV-2 entry-mediated pathways are involved in gastrointestinal tumors. The gene discussed is ACE2; the disease is digestive system neoplasm.