In the light of our findings where TRIM31 is positively correlated with TMPRSS2-TMPRSS4 in GI tumors and knockdown of TRIM31 mediates viral replication and viral processes, developing inhibitors targeting TRIM31 may decrease viral infection efficiency of SARS-CoV-2 in colorectal cancer patients. The gene discussed is TMPRSS2; the disease is colorectal cancer.