TMPRSS2 and cancer: Besides the expression of TMPRSS2, TMPRSS4, and TRIM31 in GI cancers, we have analysed the expression of these genes in all cancers, and we have found that the expression of these genes is more upregulated in majority of GI cancers than individual other cancer types (Supplementary Figure S7, Supplementary Figure S8, Supplementary Figure S9).