After TRIM31 was found to be upregulated and positively correlated with TMPRSS2 and TMPRSS4 genes in both cancer cell lines and solid tumor samples, we aimed to investigate the relationship of TRIM31 with TMPRSS2 and TMPRSS4 using the clinically relevant model system Patient Derived Organoids (PDOs)50,51. This evidence concerns the gene TMPRSS4 and cancer.