Among the significantly high expression profiles of receptors and mediator proteins for SARS-CoV-2 entry into cells in GI tumors, we observed high co-expression of TMPRSS2 and TMPRSS4 in all GI tumors demonstrating that these mucosa specific serine proteases can facilitate the entry of the spike protein into the cell membrane. Here, TMPRSS4 is linked to digestive system neoplasm.