We observed at least 3-times higher effect estimates of candidate genetic variants for severe COVID-19 compared to testing positive for SARS-CoV-2 for all remaining candidate proteins (Supplemental Data 5), making them likely candidates to contribute to disease severity, which was supported by analysis from the COVID-19 HGI for ELF5, OAS1, and SFTP15. This evidence concerns the gene OAS1 and COVID-19.