It has been recently reported that ferritin H/SLC7A11 promotes ferroptosis in cardiomyopathy,44 and iron chelators prevented myocardial ischemia-reperfusion injur.15,16 While these studies have raised concerns on how ferroptosis affect the pathophysiology of I/R at the molecular level, they mainly focused on perturbances in the reperfusion phase. This evidence concerns the gene SLC7A11 and cardiomyopathy.