Sadleir and colleagues examined the 5XFAD mice, a common model of AD overexpressing PSEN1 and APP genes [84], and showed that they do not manifest an upregulation of ER stress markers (e.g., HSPA5, IRE1, DDIT3, ATF4, and eIF2α) [84]. The gene discussed is EIF2A; the disease is Alzheimer disease.