However, findings of this study showed that pharmacological inhibition of PTEN suppressed ER stress, apoptosis, and induced phosphorylation/activation of PIK3CA (PI3K)/AKT1 (a crucial axis regulating cell division, survival, and growth, and negative regulator of apoptosis) (Fig. 2), leading to suppression of apoptosis in the hippocampus and amelioration of AD phenotype [77]. Here, PTEN is linked to Alzheimer disease.