CUBN and kidney disorder: Consequently, glycan alterations are found in many diseases and multiple studies have identified mutations in megalin and cubilin associated with kidney disease and proteinuria (60, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92).