Unexpectedly, ectopic expression of hLAMP1 has a relatively modest effect on LASV fusion/infection with endosomes across three platforms–LASVpp, LASV-VLP and recombinant LCMV/LASV-GPC viruses, even in avian cells expressing a LAMP1 ortholog that does not support LASV fusion. This evidence concerns the gene GYPC and infection.