Practically, differentiation of WNT-activated, as well as TP53 wild-type and TP53 mutant SHH-activated types may be important, and immunohistochemical stains including B-catenin, GAB1, YAP1, ALK, LEF1, and p53 can help segregate an overwhelming majority of medulloblastomas in everyday pathology practice. This evidence concerns the gene TP53 and medulloblastoma.