CTLA4 and gastric cancer: Furthermore, GSVA analysis showed that the high-FRLSG group enriched in many immune-related pathways, such as B cell receptor signaling and chemokine signaling, and CTLA4 associated pathways, such as cell adhesion molecules cams and T cell receptor signaling, which suggested GC patients with high-FRLSG might benefit from immunotherapy and anti-CTLA4 therapy (Figure 5E).