The results showed that SPIB expression was significantly upregulated in 25 out of 33 cancer types compared to adjacent normal tissues, including GBM, GBMLGG, LGG, BRCA, CESC, LUAD, ESCA, STES, KIRP, KIPAN, PRAD, STAD, KIRC, LUSC, LIHC, WT, SKCM, THCA, OV, PAAD, TGCT, UCS, ALL, LAML and CHOL (Figure 1A, 1B). This evidence concerns the gene SPIB and cancer.