Kaplan-Meier analysis showed that reduced SPIB expression in GBMLGG, LGG, KIRP, KIPAN, GBM, and UVM correlated with a poor prognosis, whereas increased SPIB expression was associated with poor prognosis in BRCA, LUAD, HNSC, SKCM, SKCM-M, and OV (Supplementary Figure 2B, 2C). The gene discussed is SPIB; the disease is glioblastoma.