We initially determined the expression of menin, MLL1 and H3K4 methylation in profibrogenic factor‐treated RTECs as well as in the kidneys of fibrotic mice or DN and diabetic patients; we presumed that the expression of the menin/MLL1 complex in kidney tubular injury was associated with renal fibrosis. The gene discussed is KMT2A; the disease is renal fibrosis.