Additionally, the transcripts of Gdf11 (FC = −1.682, p value = 1.80e−5), Adamts5 (FC = −1.508, p value = 3.55e−7), Hgf (FC = −2.664, p value = 1.54 × 10−4), Pdgfrα (FC = −1.685, p value = 2.29e−5) and Pdgfrβ (FC = −1.031, p value = 2.30 × 10−4), which are important regulators involved in the development of renal fibrosis,29, 30, 31, 32 were significantly expressed at lower levels in the Men1Δ/Δ mice. The gene discussed is ADAMTS5; the disease is renal fibrosis.