Notably, menin, HGF and Adamts5 are constitutively inactivated in the UUO‐induced TIF and patients with renal fibrosis, and they serve as critical renal fibrosis suppressors, suggesting the clinical significance of the menin‐HGF‐Adamts5 axis as a biomarker for the prognosis and assessment of renal fibrosis. The gene discussed is ADAMTS5; the disease is renal fibrosis.