Menin/MLL complexes have histone methyltransferase activity specific for H3K4me3 and play a critical role in tumourigenesis,25 hyperglycaemia58 and insulin resistance,59 but the putative biological function of menin/MLL1‐mediated H3K4me3 in renal fibrosis remains unknown. The gene discussed is MEN1; the disease is Insulin resistance.