Moreover, PIKfyve inhibition in lymphoma and neuronal cells also causes lysosome swelling and dysfunction leading to autophagosome accumulation (Martin et al, 2013; Gayle et al, 2017), consistent with a role for PIKfyve in maintaining the supply of lysosomes needed for autophagosome fusion to form autolysosomes. The gene discussed is PIKFYVE; the disease is lymphoma.