As expected, there were main effects of Obese to have increased macrophage genes CD68 (p < .0001), EMR1 (p < .0001), Itgax (p < .0001), and MRC1 (p < .0001) (Figure 8a) and increased cytokines TNFα (p < .0001), IFNγ (p = .013), and IL-10 (p < .0001) (Figure 8b); however, the inflammatory status of adipose tissue with obesity did not appear to be impacted by 5FU (i.e. there was no main effect of 5FU). Here, ADGRE1 is linked to obesity due to melanocortin 4 receptor deficiency.