TRIM8 and myocardial infarction: 2019). Abnormal expression of TRIM32 was observed in many heart diseases, such as heart failure and atrial fibrillation (Borlepawar et al. 2019). Therefore, we speculate that TRIM32 may also play a role in myocardial I/R injury, which deserves to be explored in the future. Second, although we found that TRIM8 expression was up-regulated in response to I/R injury in vitro and in vivo, it is unclear whether TRIM8 expression is altered in human myocardial infarction, which is to be clarified in the further investigations.