2019). Abnormal expression of TRIM32 was observed in many heart diseases, such as heart failure and atrial fibrillation (Borlepawar et al. 2019). Therefore, we speculate that TRIM32 may also play a role in myocardial I/R injury, which deserves to be explored in the future. Second, although we found that TRIM8 expression was up-regulated in response to I/R injury in vitro and in vivo, it is unclear whether TRIM8 expression is altered in human myocardial infarction, which is to be clarified in the further investigations. The gene discussed is TRIM8; the disease is heart failure.