SPTBN2 and neoplasm: The PTC tissues in TCGA cohort (502 patients with PTC) and our local validated cohort (48 patients with PTC) were classified individually into the high SPTBN2 expression group or the low SPTBN2 expression group in accordance with their median expression level value of SPTBN2. The results of the analyses showed that in TCGA cohort, histological type, LNM, tumor size, and disease stage were related to SPTBN2 upregulation (Table 3).