TMPRSS2 and COVID-19: Multi-organ COVID-19-related pathology which is frequently associated with severe COVID-19 (46) is attributed to direct invasion of SARS-CoV-2 via ACE2 receptors, Neuropilin 1, and Transmembrane serine 2 proteases (TMPRSS2) (47–49), COVID-19-related cytokine storm and COVID-related hypoxia (9, 50).