The research (20, 21) showed that the serum level of free insulin-like growth factor-1(IGF-1) increases, and insulin-like growth factor-binding protein-1(IGFBP-1) is low in PCOS IR patients; such alternation may drive PCOS follicles to produce excessive sheath androgen. This evidence concerns the gene IGFBP1 and polycystic ovary syndrome.