For example, some study found that exosomes could help spread tau proteins and encourage Aβ aggregation (Song et al., 2020a; Ruan et al., 2021); however, other studies reported that neuronal exosomes could restrain Aβ oligomerization, accelerate Aβ fibril formation, and facilitate microglia-mediated Aβ clearance, implying that exosomes from different cell types might exhibit different effects on the development of AD (Yuyama et al., 2012, 2014; Asai et al., 2015; Dinkins et al., 2017). Here, MAPT is linked to Alzheimer disease.