The accuracy of the combination of F, ACTH, NE, WBC, Glu, and HB in predicting poor prognosis of stroke was significantly higher than that of lesion volume (AUC: 0.931 vs. 0.694 P = 0.019) and the NIHSS score (AUC: 0.931 vs. 0.746 P = 0.034) (Figure 3). Here, POMC is linked to Stroke.