After adjustment for age, sex and the NIHSS score, F > 13.6 μg/dL and ACTH > 22.02 pg/mL were found to be risk factors for poor stroke prognosis (P < 0.05), and after adjustment for age, sex and the GCS score, NE > 123.5 μg/24 h was identified as a risk factor for poor stroke prognosis (P < 0.05). Here, POMC is linked to Stroke.