PARP1 and cardiomyopathy: The T. cruzi infection leads to ROS formation in the mitochondria, triggering PARP-1 and NF-kappaB activation, culminating in the production of pro-inflammatory cytokines such as Il-12 and IFN-γ (Ba et al., 2010), involved in cardiomyopathy pathophysiology (Cunha-Neto et al., 1998).