In sepsis-induced myocardial depression (SIMD), which is a devastating complication of sepsis with a mortality rate of greater than 50%, Kalbitz et al. discovered that the NLRP3 and IL-1β levels were greatly increased in the left ventricular cardiomyocytes of septic mouse models induced by cecal ligation and puncture (CLP). Here, NLRP3 is linked to Sepsis.