Teng et al. found that, in addition to inhibiting ROS, Nrf2 could have a protective role by upregulating C1q/tumor necrosis factor-related protein 1 (CTRP1) expression and inhibiting pyroptosis by binding to the promoter of CTRP1 in sepsis-induced myocardial injury in vivo and in vitro (Teng et al., 2022). This evidence concerns the gene NFE2L2 and Sepsis.