NLRP3 and Sepsis: For instance, Fu et al. showed that the NLRP3 inhibitor MCC950 and caspase-1 inhibitor Ac-YVAD-CMK ameliorated increased hippocampal neuronal pyroptosis and reduced the levels of pro-inflammatory cytokines and rescued cognitive deficits in mice with sepsis-associated encephalopathy (Fu et al., 2019).