The iBALT structure is maintained for a specific time even after the inflammatory response is over (Rangel-Moreno et al., 2011; Morissette et al., 2014), and considering the characteristics of iBALT, it may provide a site for the localization of protective lymphocytes such as CXCR5+ CD4+ T cells, which correlate with a better prognosis for patients with TB (Khader et al., 2011; Slight et al., 2013). Here, CD4 is linked to tuberculosis.