Moreover, the protein fraction of the conditioned medium (i.e., the cell-free medium containing biologically active components derived from previous cell growth) from the potential probiotic Akkermansia muciniphila, cultivated in mucin-depleted conditions, could induce a set of phenotypic changes that could lead to alpha-synuclein aggregation, a pivotal feature associated Parkinson’s Disease development (Amorim Neto et al., 2022). This evidence concerns the gene SNCA and Parkinson disease.