TLR2 and disease arising from reactivation of latent virus: It has been found that many substances can be used as LRAs to activate latent HIV reservoir, such as: 1) cytokines or receptor agonists, such as IL2, IL7, IL15, toll-like receptor 2,3(TLR2, 3) agonists, etc. The drugs were found to reactivate the expression of HIV, but they did not eliminate the latent infection cells, or affect the size of the HIV reservoir (Rochat et al., 2017; Madrid-Elena et al., 2018).