However, OT intervention exerted a preventive effect on obesity possibly by regulating β-oxidation of fatty acid (Ppara and Pgc1a), cholesterol removal (Lxra), lipolysis (Srebf1 and Hsl), and low-grade inflammation (Il-6 and Il-1b). The gene discussed is PPARGC1A; the disease is obesity due to melanocortin 4 receptor deficiency.