RCC can be caused by mutations in the VHL, MET (MET Proto-Oncogene, Receptor Tyrosine Kinase), FLCN (Folliculin), fumarate hydratase, succinate dehydrogenase, TSC1 (Tuberous sclerosis 1), TSC2 (Tuberous sclerosis 2), and TFE3 (Transcription Factor Binding To IGHM Enhancer 3) genes, some of which are involved in cellular respiration and energy metabolism [38]. Here, TSC2 is linked to renal cell carcinoma.