To test whether Brg1 is involved in the phenotypic transition and SCLC metastasis, we generated the Rb1L/L/Trp53L/L/Brg1L/L (RPB) mouse cohort and performed comparative analyses of tumorigenesis, SCN signature enrichment and metastasis in parallel with the RP model (Fig. 3E). Here, SMARCA4 is linked to small cell lung carcinoma.