RIPK3 and bronchopulmonary dysplasia: Studies have found that TREM-1 can reduce lung injury in neonatal mice under hyperoxia exposure through the downregulation of RIPK3-mediated necrosis and ultimately reduce lung inflammation and improve alveolarization; furthermore, phosphorylated RIPK3 and MLKL protein expression was increased in the alveolar lavage fluid in infants with BPD (57).