MLKL and acute respiratory distress syndrome: Pan et al. (24) found that RIPK1, RIPK3, and MLKL were expressed in large amounts in the lung tissue of oleic acid-induced ARDS rats and that Nec-1 pretreatment reduced the RIPK1-RIPK3 interaction, downregulated the RIPK1-RIPK3-MLKL signaling pathway, and inhibited inflammatory responses by reducing neutrophil infiltration and protein leakage into lung tissues, significantly improving lung function and reducing pulmonary edema in oleic acid-induced ARDS rats.