Our study indicated that cystatin C, RI, and KIM-1 might be associated with the risk for DKD in children and adolescents diagnosed with DM-T1, at least to the extent that it is validly indicated by the eight standard predictors: eGFR, urinary albumin, serum creatinine, duration of DM-T1, HbA1c, age, higher blood pressure percentile (systolic or diastolic, whichever were in higher percentile levels for the child of a given age and sex), and BMI. This evidence concerns the gene CST3 and diabetic kidney disease.