ACE2 and infection: 3) rVSV-SARS2-S cannot infect C57BL/6J or B6-IFNAR1 KO mice, but infects neonatal B6.Cg-Tg (K18-ACE2)2Prlmn/J demonstrating that the interaction with hACE2 is required for infection, and 4) pre-treatment with antibodies that specifically block the spike protein protected the mice from infection (Figure 4).