The CAFDL signature was significantly positively correlated with epithelial–mesenchymal transition (EMT), WNT/β-Catenin signaling, angiogenesis, and TGF-β signaling pathways across pan-cancer, which are important mechanisms that occur in the tumor stroma to promote tumor development and metastasis (Figure 7A). The gene discussed is TGFB1; the disease is cancer.