LAIR1 has been found to be associated with tumor immunosuppression and has recently been reported to block the LAIR1 and TGF-β signaling pathways to remodel the TME, making PD-L1-mediated tumor eradication possible (37).Our results also suggest that PD-L1-mediated tumor eradication could be a potential therapeutic strategy. This evidence concerns the gene CD274 and neoplasm.