Subsequently, we analyzed DEGs between tumor and normal tissues (Table S1) and selected the top five DEGs with the highest expression, which were SPP1, AKR1C2, AKR1B10, AGT, and EPHX1 in tumor tissues and NKG7, KLRD1, KLRB1, CCL5, and CST7 in normal tissues. Here, SPP1 is linked to neoplasm.