NFKB1 and diabetic kidney disease: In studies related to diabetic nephropathy, interaction between AGEs and RAGE on glomerular foot cells increases the expression of acetyl heparinase, which degrades acetyl heparan sulfate in the glomerular basement membrane (GBM) and disrupts the filtration barrier, by activating the NF-κB signaling pathway and plays an important role in diabetic nephropathy.