A recent animal experiment applied lentiviral transfection to silence RAGE expression for the first time to investigate the role of the RAGE signaling pathway in PD, further validating the involvement of RAGE in pro-inflammatory changes during PD in animal models.The results also showed that MAPK/p38 activation mediated the secretion of RAGE-NF-κB-dependent pro-inflammatory cytokines, which induced dopamine degradation in the striatum and loss of tyrosine hydroxylase neurons in the substantia nigra. The gene discussed is AGER; the disease is Parkinson disease.