The evaluation of 11 cancer-related pathways (CD8+ T effector, Antigen processing machinery, Epithelial-Mesenchymal Transition [EMT], Angiogenesis, Cell cycle, DNA replication, Nucleotide excision repair, DNA damage repair, Homologous recombination, Mismatch repair, Hypoxia) using the GSVA algorithm showed that pathways related to immune activation were significantly up-regulated in the STS samples from Cluster A, whereas, pathways related to EMT, cell cycle, and DNA replication were significantly up-regulated in the STS samples from Cluster B (Figure 2E). The gene discussed is CD8A; the disease is telomere syndrome.