Furthermore, while the Y. pseudotuberculosis T3SS effectors YopB and YopD induce NLRP3 inflammasome activation by a poorly understood mechanism, translocation of these bacterial proteins is tightly controlled by YopK during infection, which inhibits exessive translocation of these effectors (160, 161) and therefore limits NLRP3 activation (162) (Figure 2B). The gene discussed is NLRP3; the disease is infection.