Furthermore, activation of the NLRP3-inflammasome has been shown to drive immunopathology in Bacillus cereus infection, where NLRP3-induced inflammation strongly enhances the mortality of infected mice (175) and in pneumococcal meningitis, driven by IL-18 and IFN-γ (176, 177). The gene discussed is NLRP3; the disease is pneumococcal meningitis.