We demonstrate that: (1) GAS6/AXL and MERTK signaling, in a cell-autonomous way, sustains MICA expression in MM cells; (2) GAS6 secreted by BMSCs augments membrane MICA expression on MM cells at transcriptional level; (3) NF-kB pathway mediates MICA up-regulation by GAS6. Here, AXL is linked to Miyoshi myopathy.