ENTPD1 and relapsing-remitting multiple sclerosis: Of note, expansion of CD39+Tregs is induced after treatment with immunomodulatory drugs, such as fingolimod (49) or methylprednisolone (46), or alemtuzumab (50), in RRMS patients or with teriflunomide in EAE mice (51), which suggests that these cells may inhibit the inflammatory response and contribute to the remission phase of the disease via the production of ADO.