ADORA2A and myeloid sarcoma: Although these results are of relevance to AD (9) and other conditions in which the BBB impedes access of therapeutics to the CNS – including the progressive form of MS, in RRMS it may be said that using A1R and A2AR antagonists is a better therapeutic strategy to reduce BBB permeability, which is in fact observed after treatment with immunomodulatory drugs in MS (14).