CD4 and neoplasm: C3 was determined to have an “immune-hot” pattern with abundant immune cells and an elevated expression of immune checkpoints, such as CD4+ T cell, CD8+ T cell, activated dendritic cell, CD274 (PD-L1), CTLA-4, LAG3 molecular, etc. The dendritic cell initiates immune responses, and activated CD8 T cells have an anti-tumor effect, thus eliminating tumor cells (42, 46).