IL13 and allergic respiratory disease: DCs have also been demonstrated to generate Ym protein in response to IL-13 in the OVA-induced respiratory allergy, in which case Ym protein downregulated the activity of 12/15(S)-lipoxygenase (12/15-LOX) and the following products, 12-hydroxyeicosatetraenoic acid (12(S)-HETE), thereby enhancing the ability of CD4+ T cells to produce Th2 cytokines such as IL-5, IL-13, etc (61).