According to underlying IEI types, 166/452 (36.72%) Common Variable immunodeficiency (CVID), 15/31 (48.38%) X-linked (XLA) or autosomal recessive agammaglobulinemia (ARA), 7/14 patients with Good’s Syndrome (50%), 3/9 (33.33%) patients with Hyper-IgE disease, 1/2 patients with IFNγR deficiency (50%) were SARS-CoV-2 infected. This evidence concerns the gene IGHE and common variable immunodeficiency.