HAVCR2 and neoplasm: Tumors form an immunosuppressive tumor microenvironment (TME) by secreting cytokines like TGF-β and overexpressing co-inhibitory immune checkpoints such as Programmed Cell Death Protein 1(PD-1, CD279)/Programmed Death-ligand 1 (PD-L1), T cell Immunoglobulin domain, and Mucin domain 3 (TIM-3, CD366)/Galectin9, and Lymphocyte Activation Gene 3 (LAG-3) (27, 28).