Notably, LDMTX had no apparent anti-inflammatory effect in either the CIRT trial of nearly 5000 participants with stable ASCVD or in our own trial of 129 adequately-dosed PWH on ART with sustained virus suppression – in both studies, plasma levels of IL-1β, IL-6, and CRP all remained stable (12, 14). The gene discussed is CRP; the disease is atherosclerosis.