TP53 and central nervous system cancer: The six OS-related differentially CRGs were significantly enriched in the citrate cycle (TCA cycle); pyruvate metabolism; glycolysis/gluconeogenesis; carbon metabolism; biosynthesis of cofactors; glyoxylate and dicarboxylate metabolism; propanoate metabolism; glycine, serine, and threonine metabolism; bladder cancer; tryptophan metabolism; valine, leucine, and isoleucine degradation; lysine degradation; central carbon metabolism in cancer; melanoma; non-small cell lung cancer; platinum drug resistance; p53 signaling pathway; glioma; pancreatic cancer; and chronic myeloid leukemia (Figure 2B).