Thus, we identified hub ISGs in the PPI network and found that there were strong interactions among IFIT1, RSAD2, IFIT3, USP18, ISG15, OASL, MX1, OAS2, OAS3, and IFI44, all of which are meanwhile potential biomarkers closely involved in SLE. This evidence concerns the gene USP18 and systemic lupus erythematosus.