Thus, we identified hub ISGs in the PPI network and found that there were strong interactions among IFIT1, RSAD2, IFIT3, USP18, ISG15, OASL, MX1, OAS2, OAS3, and IFI44, all of which are meanwhile potential biomarkers closely involved in SLE. Here, IFIT3 is linked to systemic lupus erythematosus.