CD226 and neuroblastoma: Overall, these data indicated that in our model i) DNAM-1-engineered NK cells had an enhanced ability to recognize NB cell lines such as LA-N-5 and SMS-KCNR, ii) that the CD3ζ sequence in frame with DNAM-1 further enhanced this function, which was maintained by DNAM-1 intracellular domain, but did not require the 2B4 costimulatory sequence.