In contrast, the rates of TIM-3+CD4+ T cells in the blood of our AD patients were negatively correlated, albeit weakly, with those of TH17 cells (r =-0.4372, P <0.05, Figure 5C), and, additionally, with those of TH1 cells (r =-0.4652, P <0.01, Figure 5D). The gene discussed is CD4; the disease is Alzheimer disease.