LGALS9 and Alzheimer disease: Serum levels of Gal-9, in our AD patients, were also positively and negatively correlated with circulating TH22 cells (r=0.5904, P <0.001, Figure 6A) and TH17 cells (r =-0.4647, P <0.01, Figure 6C), respectively, suggesting that Gal-9, via TIM-3, downregulates TH1/TH17-immunity and drives TH2/TH22 polarization.