AD patients with high serum levels of Gal-9 had markedly higher rates of TIM-3+CD4+ T cells as compared toAD patients with low serum levels ofGal-9 (32.5 ± 4%vs 19.3± 3.9%, P=0.029, Figure 2B).Vice versa, patients with high rates of TIM-3+CD4+ T cells had markedly higher serum levels of Gal-9 than patients with low rates (3,532 ± 253 vs 2,456 ± 273 pg/ml, P=0.0074, Figure 2C). The gene discussed is HAVCR2; the disease is Alzheimer disease.