In ACPA- RA, MMP-3 was positively correlated with ESR (r = 0.396, p < 0.001), CRP (r = 0.449, p < 0.001), VEGF (r = 0.347, p < 0.001), and DAS28-ESR (3) (r = 0.327, p < 0.001), and negatively correlated with the lymphocyte percentage (r = −0.394, p < 0.001), CD4+ T cells (r = −0.231, p = 0.006), CD8+ T cells (r = −0.230, p = 0.007), Th1 cells (r = −0.305, p < 0.001) and Th17/Treg ratio (r = −0.278, p = 0.003) (Figures 6A, B). The gene discussed is CD8A; the disease is rheumatoid arthritis.