In ACPA+ RA, MMP-3 was positively correlated with ESR (r = 0.314, p < 0.001), CRP (r = 0.344, p < 0.001), and VEGF (r = 0.344, p < 0.001) and negatively correlated with the lymphocyte percentage (r = −0.260, p = 0.002) (Figure 6A, Supplementary Figure S2B). This evidence concerns the gene MMP3 and rheumatoid arthritis.