In fact, translocation of Spn across cerebrovascular endothelium has been demonstrated in both In vitro experiments and mouse models (67).Therefore, our model is based on the premise that in bacterial meningitis, microbial products, functioning as pathogen associated molecular patterns that stimulate innate immune receptors are present in the perivascular space, where they can therefore trigger innate immune inflammatory responses by perivascular macrophages. The gene discussed is SPN; the disease is bacterial meningitis.