Moreover, by another large sample GWAS, the causal effect of IL-6, IL-8, and IL-18 levels on OSA were still negative, with the OR of 0.853, 95% CI = (0.701, 1.039), and p = 0.114 for IL-6; OR of 0.982, 95% CI = (0.713, 1.353), and p = 0.912 for IL-8; and OR of 0.975, 95% CI = (0.941, 1.010), and p = 0.157 for IL-18 (Supplemental Table 8 and Supplemental Figure 8B). Here, CXCL8 is linked to obstructive sleep apnea syndrome.